Bronchopulmonary dysplasia Twenty-five Years Later. It is formed by type II pneumocytes from about 20 weeks of gestation. Clinical : ... Embryology. Our new CrystalGraphics Chart and Diagram Slides for PowerPoint is a collection of over 1000 impressively designed data-driven chart and editable diagram s guaranteed to impress any audience. The major components of pulmonary surfactant include phospholipids (∼80%), neutral lipids (mainly cholesterol, ∼10%), and the two hydrophobic peptides (1–2%) surfactant protein B (SP-B) and SP-C. Bates, PhD, DSc Research Professor of Medicine Vermont Lung Center, - Title: Targeted Therapies for Advanced Non-Small Cell Lung Cancer Author: Can Ozturk Last modified by: CAN OZTURK Created Date: 9/29/2005 4:26:22 AM, Lung Mechanics: Theory and Practice I The Basics of Measuring Lung Mechanics. World's Best PowerPoint Templates - CrystalGraphics offers more PowerPoint templates than anyone else in the world, with over 4 million to choose from. Pulmonary surfactant is a surface-active lipoprotein complex formed by type II alveolar cells.The proteins and lipids that comprise surfactant have both a hydrophilic region and a hydrophobic region. Looks like you’ve clipped this slide to already. - Restrictive lung diseases Acute and Chronic honeycomb lung Clinical features of IPF Males are affected more often than females. Surfactant in Preterm Infants Introduction Pulmonary surfactant is a complex mixture of phospholipids and proteins that serves to reduce alveolar surface tension. Physiologic concepts. Surfactant is an agent that decreases the surface tension between two media. Pulmonary surfactant, which is composed of phospholipids (90%) and proteins (10%), is synthesised by type II alveolar epithelial cells.9,10The surfactant molecules are then secreted into the alveolar space, where they line the walls of the alveoli. List the surfactant proteins. Pulmonary alveolar proteinosis is a rare but potentially treatable disease, characterized by impaired surfactant metabolism that leads to accumulation in the alveoli of proteinaceous material rich in surfactant protein and its component. Pulmonary surfactant is a complex mixture of phospholipids, neutral lipids, and specific proteins; it is produced by the alveolar type II epithelial cell (AEC2), stored in intracellular organelles known as lamellar bodies, and secreted by exocytosis into the alveolar lumen. It's FREE! Smoke exposure is known to decrease total pulmonary surfactant and alter its composition, but the role of surfactant in chronic obstructive pulmonary disease (COPD) remains unknown. Surfactant was the first drug developed solely for treatment of neonates; a major breakthrough in neonatal medicine in the past 35 years. Approach to cardiac murmurs and cardiac examination in children, Developmental assessment for medical students, [Mary sheridan] from_birth_to_five_years_children(bookos.org)[1], 7 breastfeeding the premature and the sick term baby. 1. Surfactant replacement therapy in preterm neonates: A comparison of postmortem pulmonary histology in treated and untreated infants. A mixture of phospholipids and protein ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 120db9-NjIzO. Type 2 Alveolar Cells - secrete surfactant Surfactant = substance that decreases surface … The Basics of Measuring Lung ... A. presentations for free. Reason No. Summary Pulmonary surfactant is a complex mixture of specific lipids, proteins and carbohydrates, which is produced in the lungs by type II alveolar epithelial cells. B. SURFACTANT 2. Pulmonary endothelial and alveolar epithelial injury permeability edema Surfactant dysfunction Maladaptive repair with mesenchymal cells and proliferative fibroblasts Alveolar edema and proteins are cleared, endothelial and epithelial injury repaired Acute hypoxemia, Increased dead space Venous admixture (V/Q mismatch) Low compliance Pulmonary Do you have PowerPoint slides to share? Summary Pulmonary surfactant is a complex mixture of specific lipids, proteins and carbohydrates, which is produced in the lungs by type II alveolar epithelial cells. See our Privacy Policy and User Agreement for details. In this method, the surface tension at an air/water interface is directly measured by a small plate attached to an electro balance. t2. One of the first model systems used to examine surface activity of several surfactant components was the LangmuirWilhelmy balance, introduced by Clements [81]. By adsorbing to the air-water interface of alveoli, with hydrophilic head groups in the water and the hydrophobic tails facing towards the air, the main lipid component of surfactant, dipalmitoylphosphatidylcholine (DPPC), reduces surface tension. Pathology. Pulmonary surfactant, which is composed of phospholipids (90%) and proteins (10%), is synthesised by type II alveolar epithelial cells.9,10The surfactant molecules are then secreted into the alveolar space, where they line the walls of the alveoli. - Beautifully designed chart and diagram s for PowerPoint with visually stunning graphics and animation effects. - Pulmonary Mechanics and Graphics during Mechanical Ventilation Definition Mechanics: Expression of lung function through measures of pressure and flow: Derived ... - New treatment options for lung cancer Lung cancer is a leading cause of death world wide 90% of lung cancer is caused by smoking 20% of patients are suitable for ... - Radiofrequency Ablation of Lung Cancer Andrew R. Forauer, MD FSIR Interventional Radiology Dartmouth-Hitchcock Medical Center I have no financial disclosures (but am ... - Lung cancer Edit Csada MD 08.10.2014. If you continue browsing the site, you agree to the use of cookies on this website. It is formed by type II pneumocytes from about 20 weeks of gestation. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Pulmonary alveolar proteinosis (PAP) is a rare respiratory syndrome characterised by the accumulation of surfactant lipoproteins within the alveoli. Pulmonary endothelial and alveolar epithelial injury permeability edema Surfactant dysfunction Maladaptive repair with mesenchymal cells and proliferative fibroblasts Alveolar edema and proteins are cleared, endothelial and epithelial injury repaired Acute hypoxemia, Increased dead space Venous admixture (V/Q mismatch) Low compliance Pulmonary The pulmonary surfactant is produced by the alveolar type-II … It’s 97% of total lung surface area where most gas exchange occurs. Bates, PhD, DSc Research Professor of Medicine. Bronchoalveolar lavage (BAL) fluid … The pulmonary surfactant is produced by the alveolar type-II … Pulmonary surfactant (PS) replacement therapy has been established as a safe and effective treatment for immaturity-related surfactant deficiency since the early 1990s. Lung Transplantation: Where Are We in 2011? Now customize the name of a clipboard to store your clips. Toti P, Buonocore G, Rinaldi G, Catella AM, Bracci R. Pulmonary pathology in surfactant-treated preterm infants with respiratory distress syndrome: An autopsy study. The major lipid present in pulmonary surfactant is phosphatidylcholine (PC), a large fraction of which contains two palmitic acid side chains … Type II. It’s 97% of total lung surface area where most gas exchange occurs. Whether your application is business, how-to, education, medicine, school, church, sales, marketing, online training or just for fun, PowerShow.com is a great resource. That's all free as well! Surfactant (Physiology) 1. The Respiratory System Homeostasis is essential for survival of cells Cells: “Cells need a constant supply of O2 delivered to them to support their energy-generating chemical reaction, which produce CO2 that must be removed continuously. The PL are assembled in the endoplasmic reticulum and the Golgi apparatus of alveolar type II cells and are stored in lamellar bodies until exocytosis (Fig. 18. Type II epithelial cells synthesize and assemble the lipid and protein components into complexes that are stored as tightly packed membranes in lamellar bodies until secreted into the … Pulmonary surfactant is made by our lungs and decreases the surface tension so we can breathe. •Surfactant is a surface acting material or agent that is responsible for lowering the surface tension of a fluid. Lung Mechanics: Theory and Practice V Lung Mechanics in Mouse Models of Pulmonary Disease, - Lung Mechanics: Theory and Practice V Lung Mechanics in Mouse Models of Pulmonary Disease Jason H.T. If you continue browsing the site, you agree to the use of cookies on this website. •Surfactant that lines the epithelium of the alveoli in lungs is known as pulmonary surfactant and it decreases the surface tension on the alveolar membrane. The lung and the Upper Respiratory Tract -1. Novel insights from an animal model aided the discovery of granulocyte macrophage colony stimulating factor (GM-CSF) antibodies as a pathogenetic mechanism … Overview. Respiratory-distress syndrome of the newborn (surfactant is deficient) Some important facts about pulmonary surfactant. - Introduce additional lung units with mismatch between V and Q ... Hyperventilation defined as PACO2 40. Direct measurement with a spirometer. The surface tension between gaseous- aqueous interphase in the lungs is decreased by the presence of a thin layer of fluid known as pulmonary surfactant. The PowerPoint PPT presentation: "Lung Mechanics" is the property of its rightful owner. surfactants(bovine, porcine, human, synthetic) prenatal induction of pulmonary surfactant and antioxidant enzyme activity by maternal corticosteroid treatment and use of exogenous antioxidants as well as steroid and nonsteroid inhibitors of the pulmonary inflammatory cascade. Pulmonary administration is widely used for the treatment of lung diseases. Objectives To reprogram non-small cell lung cancer (NSCLC) ... - Measuring Neonatal Lung Volume Advisor: Dr. Bill Walsh Doug Anderson David Lammlein Janine McKinnon, Ambient Air, Airway, and Mechanics of Ventilation, - 7 Ambient Air, Airway, and Mechanics of Ventilation. See our User Agreement and Privacy Policy. Surfactant proteins. Pulmonary surfactant is a complex mixture of phospholipids (PL), neutral lipids [particularly cholesterol (Chol)], and proteins. Pulmonary surfactant has both protein and lipid components. 1... VentilationPerfusion Relationships in the Lung. The assembly of the surfactant proteins into lamellar bodies is less clear and may proceed via the endoplasmic reticulum and Golgi apparatus to multivesicular bodies before combining with the lamellar bodies (10). Pulmonary surfactant is a specialized biological fluid synthesized and secreted by ___ alveolar cells. Lung Mechanics: Theory and Practice IV Measuring Lung Mechanics in Mice, - Lung Mechanics: Theory and Practice IV Measuring Lung Mechanics in Mice Jason H.T. A mixture of phospholipids and protein... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 120db9-NjIzO - Part 2 Mechanical Properties of the Lung and Chest Wall: Static and Dynamic 2. M1a = Separate tumor nodule(s) in a contralateral lobe tumor with pleural nodules or ... Part 2 Mechanical Properties of the Lung and Chest Wall: Static and Dynamic. Pulmonary surfactant represents a complex mixture of what? CrystalGraphics 3D Character Slides for PowerPoint, - CrystalGraphics 3D Character Slides for PowerPoint. Boasting an impressive range of designs, they will support your presentations with inspiring background photos or videos that support your themes, set the right mood, enhance your credibility and inspire your audiences. Clipping is a handy way to collect important slides you want to go back to later. Pulmonary surfactant is a complex mixture of phospholipids and proteins that serves to reduce alveolar surface tension. Primary PAP is led by a granulocyte–macrophage colony-stimulating factor (GM-CSF) signalling disruption; the autoimmune … Furthermore, CO2 generates carbonic acid with which the body must continuously deal in order to maintain the proper pH in the internal environment. Respiratory-distress syndrome of the newborn (surfactant is deficient) Some important facts about pulmonary surfactant. 1. And they’re ready for you to use in your PowerPoint presentations the moment you need them. Winner of the Standing Ovation Award for “Best PowerPoint Templates” from Presentations Magazine. Lung Compliance Lung compliance (CL) is a measure of the elastic properties of the lung ... - Mechanics of Breathing Breathing Inspiration: ... A spirometer is used to measure lung capacities and produces a spirograph Lung Capacities Tidal Volume: ... Reversal of Aberrant Cancer Methylome and Transcriptome upon Direct Reprogramming of Lung Cancer Cells. 6 breastfeeding and drugs and acceptable medical reasons for artificial feedi... No public clipboards found for this slide. Pulmonary surfactant is a complex of highly active phospholipids and proteins that cover the alveolar epithelial surface of the lungs 1. … Other advantages are that radiography and epifluorescent microscopy of the surface f… As a result, pulmonary surfactant reduces the surface tension of the liquid lining, decreasing the pressure needed to keep the alveoli inflated and maintaining alveolar stability. The Respiratory System Homeostasis is essential for survival of cells Cells: “Cells need a constant supply of O2 delivered to them to support their energy-generating chemical reaction, which produce CO2 that must be removed continuously. Surfactant is an agent that decreases the surface tension between two media. Surfactant is synthesized in the alveolar type-II cells, stored in the lamellar bodies, and secreted to the alveolar space where it undergoes complex changes 2. Many of them are also animated. We examined the effects of Survanta and surfactant protein A (SP-A) on fibroblast growth and apoptosis and on type I collagen, collagenase-1, and tissue … PPT – Lung Mechanics PowerPoint presentation | free to view - id: 120db9-NjIzO. •SpA •SpB •SpC •SpD. What are surfactant proteins covered by? ... RADIOLOGICAL EXAMINATION OF THE LUNG AND PLEURA. Furthermore, CO2 generates carbonic acid with which the body must continuously deal in order to maintain the proper pH in the internal environment. The mixture is surface active and acts to decrease surface tension at the air–liquid interface of the alveoli. Anatomic concepts. Winner of the Standing Ovation Award for “Best PowerPoint Templates” from Presentations Magazine. One of the major advantages of this system is that a well-defined monolayer of lipids and proteins can be spread at the air/liquid surface. We aimed to analyze the compositional changes in the surfactant lipidome in COPD and identify specific lipids associated with pulmonary function decline. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Rationale: Patients with acute lung injury have impaired function of the lung surfactant system.Prior clinical trials have shown that treatment with exogenous recombinant surfactant protein C (rSP-C)-based surfactant results in improvement in blood oxygenation and have suggested that treatment of patients with severe direct lung injury may decrease mortality. More specifically, it has been found that phosphatidylcholine (PC) is the most abundant phospholipid (70%–85%), and that PC is primarily present as dipalmitoylphosphatidylcholine (DPPC). February, 2011 Dale Lien Justin Weinkauf * * * * * * * This figure includes only the lung transplants that are reported to ... - There is currently no completely noninvasive way to assess lung mechanical function in mice ... why chamber pressure varies as a mouse breathes? Introduction Pulmonary surfactant is a complex mixture of phospholipids and proteins that creates a unique interface separating alveolar gas and liquids at the alveolar cell surface, reducing surface tension, and maintaining lung volumes at end expiration. t1. - Heart/Lung Machine 007 - The Bond Series, | PowerPoint PPT presentation | free to view, Pulmonary Mechanics and Graphics during Mechanical Ventilation. 1). The proteins and lipids that make up the surfactant have both hydrophilic and hydrophobic regions. Pulmonary surfactant is a surface-active lipoprotein complex formed by type II alveolar cells.The proteins and lipids that comprise surfactant have both a hydrophilic region and a hydrophobic region. According to various pathogenetic mechanisms and aetiologies, PAP is classified as primary, secondary or congenital. - Lung Mechanics: Theory and Practice I. - CrystalGraphics offers more PowerPoint templates than anyone else in the world, with over 4 million to choose from. t3. The interaction between drug molecules and pulmonary surfactants affects the efficacy of the drug directly. Decreasing V/Q produces lower PAO2 and higher PACO2. The surface tension between gaseous- aqueous interphase in the lungs is decreased by the presence of a thin layer of fluid known as pulmonary surfactant. Or use it to find and download high-quality how-to PowerPoint ppt presentations with illustrated or animated slides that will teach you how to do something new, also for free. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect. Current influenza vaccines only confer protection against homologous viruses. During lung injury, fibroblasts migrate into the alveolar spaces where they can be exposed to pulmonary surfactant. There is a significant disturbance of the pulmonary surfactant system in MAS, with a wealth of experimental data indicating that inhibition of surfactant function in the alveolar space is an important element of the pathophysiology of the disease. Type 2 Alveolar Cells - secrete surfactant Surfactant = substance that decreases surface … Lung Mechanics: Theory and Practice III Impedance, - Lung Mechanics: Theory and Practice III Impedance Jason H.T. Bates, PhD, DSc Research Professor of Medicine Vermont Lung Center University of Vermont College of Medicine. Some new synthetic surfactants containing protein analogues, including CHF5633, have recently been studied. Pulmonary surfactant is a surface-active lipoprotein complex (phospholipoprotein) formed by type II alveolar cells. Surfactant creates a continuously reforming surface layer - The lung and the Upper Respiratory Tract -1 Atelectasis Obstructive Lung Disease Thoracic Assessment Breath Sounds absent or decreased Atelectasis: Pneumothorax ... - Toxic responses of the lung Environmental health and toxicology Lecture 7 Lecture Objectives Content Respiratory system Stages of lung toxic responses Workplace ... - Embryology. Pulmonary surfactant is a complex mixture of lipids and proteins that reduces surface tension at the interface between air and liquid. According to LaPlaces law, the pressure (P) necessary to keep the sphere open is proportional to the surface tension (T) and inversely proportional to the radius (R) of the sphere, shown by the formula P = 2T/R If … Surfactant reduced both neonatal mortality and pulmonary air leaks by about 50%. And, best of all, most of its cool features are free and easy to use. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect. Overview. The mixture is surface active and acts to decrease surface tension at the air–liquid interface of the alveoli. Or use it to create really cool photo slideshows - with 2D and 3D transitions, animation, and your choice of music - that you can share with your Facebook friends or Google+ circles. - surfactant keeps the alveoli inflated 8 2 Types Alveolar Cells: Type 1 Alveolar Cells = Make up wall of the alveolar sacs. Northway WH. Or use it to upload your own PowerPoint slides so you can share them with your teachers, class, students, bosses, employees, customers, potential investors or the world. * Staging 6 M0 = No distant metastasis. Integration of flow. Pulmonary surfactant is produced by cells within the lungs and decreases surface tension by breaking bonds between water molecules. The source(s) … They are all artistically enhanced with visually stunning color, shadow and lighting effects. Pediatr Pathol 1994;14:945-53. PowerShow.com is a leading presentation/slideshow sharing website. If so, share your PPT presentation slides online with PowerShow.com. Flow. - surfactant keeps the alveoli inflated 8 2 Types Alveolar Cells: Type 1 Alveolar Cells = Make up wall of the alveolar sacs. - Lung Transplantation: Where Are We in 2011? You can change your ad preferences anytime.

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